Drug Interactions

This FSRH Guidance provides evidence-based recommendations and good practice points for health professionals on drug Interaction with Hormonal Contraception. It is intended for use by health professionals working in sexual and reproductive health, general practice, and obstetric and gynaecology settings.

This FSRH Guidance provides key information and good practice points for health professionals on drug-drug interactions (DDIs) between HIV antiretroviral therapy (ART) and contraception to facilitate the prescription of safe and effective contraception to people living with HIV and on ART.

This statement is a response to a new paper published in BMJ Evidence Based Medicine Journal suggesting that antibiotics may lessen the effectiveness of hormonal contraception.

St Johns wort is a herbal product that is used for depressive symptoms and is known to have enzyme-inducing effects on cytochrome p450 enzymes. The MHRA statement highlights that in the last quarter of 2013, two ‘Yellow Card’ reports were received relating to unplanned pregnancies, in women with progestogen-only implants, suspected to be the result of an interaction with St John’s wort.