Growth Factors, Gametes and Gonads - 5&6 September 2019 - Cambridge

Date: 05 Sep 2019 - 06 Sep 2019

Start time: 01:00PM

End time: 08:30PM

Venue: University of Cambridge

Fitzwilliam College

Storey’s Way

Cambridge

CB3 0DG

Cost: £200/ £120 - Early Career/Post-doc/Retired

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Growth Factors, Gametes and Gonads - 5&6 September 2019 - Cambridge

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The development of functional gonads and the production of mature gametes requires precise control of cellular development, often over many months. Growth factor signals are critical regulators of every stage of gametogenesis and gonadogenesis, yet our understanding of how these signals exert their effects and how different signalling pathways converge within these tissues remains limited. Elucidating these processes will provide insight into the biology of gonadal development and function, identify novel targets for contraceptive development, and lead to the development of new treatment strategies for infertility and gonadal pathologies.

The aim of this Society for Endocrinology themed scientific meeting is to bring together experts working on different aspects of growth factor signalling in the formation, development and function of the mammalian gonads. This includes (i) sex determination and early gonadal development, (ii) the activation and maintenance of gametogenesis and (iii) how dysregulation of signalling can result in gonadal pathologies and fertility challenges.

With an outstanding programme of expert speakers, this meeting offers both established and early career researchers the opportunity to hear the latest advancements in the field, and present their own new and unpublished data. By highlighting commonalities and convergences between signalling pathways, developmental stages and reproductive function in male and female gonads, we hope the meeting will enable attendees to forge new collaborations to advance the work in the field.

Programme

 

13:00-20:30

Day 1 - Thursday 5 September 2019

13.00-14.00

Arrival and Registration

Session 1: Signalling for sex determination

14.00-14.30

Andy Greenfield (MRC Harwell/Oxford)

"MAPKs and Wnt signalling in sex determination and gonadogenesis"

14.30-15.00

Serge Nef (Geneva)

"IGF signalling in sex determination"

15.00

Coffee

Session 2: Signalling for gonadal development

15.30-16.00

Stine Kristensen (Copenhagen)

"Exploring signalling networks in human follicles through transcriptomics"

16.00-16.30

Andre Childs (London)

"TGF-beta signalling in the fetal ovary"

16.30-17.00

Anne Jorgenson (Copenhagen)

"Nodal singalling in the fetal testis"

17.15

Plenary

Clause Yding Andersen (Copenhagen)

"Signalling in fertility restoration and preservation"

18.00

Drinks Reception and Poster Viewing

19.30

Dinner

20.30

End of Day 1

Day 2

Friday 6 September 2019

08.00

Registration 

Session 3: Signalling to start gametogenesis

09.30

Susanna Dolci (Rome)

"Growth factor regulation of spermatogonial stem cell activity and differentiation (Kit, Fgf, RA)" 

 10.00

Mark Fenwick (Sheffield)

"TGF-beta regulation of follicle activation" 

 10.30

Jenny Visser (Rotterdam)

"Maintenance of  the ovarian follicle pool by AMH" 

 11.00

Coffee

Session 4: Signalling to maintain/complete gametogenesis 

11.30

Kate Hardy (London)

"Convergence of EGF and steroid signalling in the ovary"

 

12.00

Ilpo Huhtaniemi (Turku)

"inhibin/FSH/androgen interactions in spermatogenesis"

12.30

Lunch and poster viewing

Session 4: Dysregulated signalling in reproduction

13.30

Steve Franks (London)

"Dysregulated signalling in PCOS"

 14.00

Simon Langdon (Edinburgh)

"Dysregulated EGF/HER/Steroid signalling in ovarian cancer" 

14.30

Closing remarks